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Screening of the HBx transactivation domain interacting proteins and the function of interactor Pin1 in HBV replication

8 Jul 2021

Abstract excerpt

Abstract Hepatitis B virus (HBV) X protein (HBx) has been determined to play a crucial role in the replication and transcription of HBV, and its biological functions mainly depend on the interaction with other host proteins. This study aims at screening the proteins that bind to the key functional domain of HBx by integrated proteomics. Proteins that specifically bind to the transactivation domain of HBx were...

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PMID: 34238995
DOI: 10.1038/s41598-021-93584-z

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