Article
Diverse rescue potencies of p53 mutations to ATO are predetermined by intrinsic mutational properties.
Science translational medicine - 5 Apr 2023
Song Huaxin, Wu Jiale, Tang Yigang, Dai Yuting, Xiang Xinrong, Li Ya, Wu Lili, Wu Jiaqi, Liang Ying, Xing Yangfei, Yan Ni, Li Yuntong, Wang Zhengyuan, Xiao Shujun, Li Jiabing, Zheng Derun, Chen Xinjie, Fang Hai, Ye Chenjing, Ma Yuting, Wu Yu, Wu Wen, Li Junming, Zhang Sujiang, Lu Min
Abstract excerpt
Tumor suppressor p53 is inactivated by thousands of heterogeneous mutations in cancer, but their individual druggability remains largely elusive. Here, we evaluated 800 common p53 mutants for their rescue potencies by the representative generic rescue compound arsenic trioxide (ATO) in terms of transactivation activity, cell growth inhibition, and mouse tumor-suppressive activities. The rescue potencies were...
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