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Article

Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.

Cancer cell - 15 May 2012

Swartling Fredrik J, Savov Vasil, Persson Anders I, Chen Justin, Hackett Christopher S, Northcott Paul A, Grimmer Matthew R, Lau Jasmine, Chesler Louis, Perry Arie, Phillips Joanna J, Taylor Michael D, Weiss William A

Abstract excerpt

The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we transduced wild-type or mutationally stabilized murine N-myc(T58A) into neural stem cells (NSCs) from perinatal murine cerebellum, brain stem, and forebrain. Transplantation of N-myc(WT) NSCs was insufficient for tumor formation. N-myc(T58A) cerebellar...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22624711
DOI: 10.1016/j.ccr.2012.04.012
PMCID: PMC3360885

Genes

SHH
MYC
MYCN
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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