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Identification of Mammalian Proteins Cross-linked to DNA by Ionizing Radiation

10 Aug 2005

Abstract excerpt

Ionizing radiation (IR) is an important environmental risk factor for various cancers and also a major therapeutic agent for cancer treatment. Exposure of mammalian cells to IR induces several types of damage to DNA, including double- and single-strand breaks, base and sugar damage, as well as DNA-DNA and DNA-protein cross-links (DPCs). Little is known regarding the biological consequences of DPCs. Identifying...

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PMID: 16093242
DOI: 10.1074/jbc.m502477200

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