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Article

Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities.

The Journal of biological chemistry - 17 Dec 2004

Spiegel P Clint, Murphy Paul, Stoddard Barry L

Abstract excerpt

Factor VIII (fVIII) is a plasma glycoprotein that functions as an essential cofactor in blood coagulation. Its carboxyl-terminal "C2" domain is responsible for binding to both activated platelet surfaces and von Willebrand factor. We characterized the effect of 20 hemophilia-associated missense mutations across this domain (that all occur in patients in vivo) on its stability and its binding activities. At least...

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Identifiers

PMID: 15471879
DOI: 10.1074/jbc.M409389200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities.PMID 15471879Read ↗

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