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Article

Heterozygous carriage of a dysfunctional Toll-like receptor 9 allele affects CpG oligonucleotide responses in B cells.

The Journal of biological chemistry - 13 Jul 2012

Knezević Jelena, Pavlinić Dinko, Rose William A, Leifer Cynthia A, Bendelja Kreso, Gabrilovac Jelka, Parcina Marijo, Lauc Gordan, Kubarenko Andriy V, Petricevic Branka, Vrbanec Damir, Bulat-Kardum Ljiljana, Bekeredjian-Ding Isabelle, Pavelić Jasminka, Dembić Zlatko, Weber Alexander N R

Abstract excerpt

Toll-like receptors (TLR) are employed by the innate immune system to detect microbial pathogens based on conserved microbial pathogen molecules. For example, TLR9 is a receptor for CpG-containing microbial DNA, and its activation results in the production of cytokines and type I interferons from human B cells and plasmacytoid dendritic cells, respectively. Both are required for mounting an efficient...

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Identifiers

PMID: 22613717
DOI: 10.1074/jbc.M111.337477
PMCID: PMC3397879

Genes

TLR9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heterozygous carriage of a dysfunctional Toll-like receptor 9 allele affects CpG oligonucleotide responses in B cells.PMID 22613717Read ↗

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