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Article

Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399ile are hypo-responsive to Porphyromonas gingivalis.

Genes and immunity - 1 Apr 2006

Kinane D F, Shiba H, Stathopoulou P G, Zhao H, Lappin D F, Singh A, Eskan M A, Beckers S, Waigel S, Alpert B, Knudsen T B

Abstract excerpt

The Toll-like receptor (TLR)4 is the major sensor for bacterial lipopolysaccharide and its two common co-segregating polymorphisms, Asp299Gly and Thr399Ile, which occur at a frequency of between 6 and 10%, have been associated with infectious diseases, LPS hypo-responsiveness and cardiovascular disease. Porphyromonas gingivalis is a Gram-negative bacterium implicated in chronic periodontitis and is a known TLR4...

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Source

Identifiers

PMID: 16437123
DOI: 10.1038/sj.gene.6364282

Genes

TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399ile are hypo-responsive to Porphyromonas gingivalis.PMID 16437123Read ↗

Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling.Semantic proximity Read ↗

Alveolar bone loss in relation to toll-like receptor 4 and 9 genotypes and Porphyromonas gingivalis carriage.Semantic proximity Read ↗

Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease.Semantic proximity Read ↗

TLR4 Asp299Gly polymorphism may be protective against chronic periodontitis.Semantic proximity Read ↗

Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism.Semantic proximity Read ↗

Lipopolysaccharide-induced immune responses in relation to the TLR4(Asp299Gly) gene polymorphism.Semantic proximity Read ↗

Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles.Semantic proximity Read ↗

IL-10 release requires stronger toll-like receptor 4-triggering than TNF: a possible explanation for the selective effects of heterozygous TLR4 polymorphism Asp(299)Gly on IL-10 release.Semantic proximity Read ↗

TLR2 Arg753Gly, TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population.Semantic proximity Read ↗

The TLR4 D299G and T399I SNPs are constitutively active to up-regulate expression of Trif-dependent genes.Semantic proximity Read ↗

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