Article
Insulin resistance undermines the advantages of IL28B polymorphism in the pegylated interferon alpha-2b and ribavirin treatment of chronic hepatitis C patients with genotype 1.
Journal of hepatology - 1 Sept 2012
Ogawa Eiichi, Furusyo Norihiro, Murata Masayuki, Ikezaki Hiroaki, Ihara Takeshi, Hayashi Takeo, Toyoda Kazuhiro, Taniai Hiroaki, Okada Kyoko, Kainuma Mosaburo, Hayashi Jun
Abstract excerpt
BACKGROUND & AIMS: Recent studies have suggested that insulin resistance exerts a strong influence on chronic hepatitis C virus (HCV) infection. We analyzed pretreatment factors useful for predicting sustained virological response (SVR), especially interleukin (IL) 28B polymorphism and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). METHODS: This cohort study consisted of 328 chronic hepatitis C...
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