Article
Insulin resistance is a major determinant of sustained virological response in genotype 1 chronic hepatitis C patients receiving peginterferon alpha-2b plus ribavirin.
Alimentary pharmacology & therapeutics - 1 Jan 2009
Chu C-J, Lee S-D, Hung T-H, Lin H-C, Hwang S-J, Lee F-Y, Lu R-H, Yu M-I, Chang C-Y, Yang P-L, Lee C-Y, Chang F-Y
Abstract excerpt
BACKGROUND: Cross-sectional studies suggest insulin resistance is strongly associated with hepatic steatosis and fibrosis in patients with chronic hepatitis C (CHC), which might affect the efficacy of antiviral therapy. Aim To investigate retrospectively the impact of insulin resistance on treatment response in Chinese genotype 1 CHC patients receiving a 24-week course therapy with peginterferon...
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