Article
Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice.
Epilepsia - 1 Aug 2012
Bessaïh Thomas, de Yebenes Esther Garcia, Kirkland Kyle, Higley Michael J, Buono Russell J, Ferraro Thomas N, Contreras Diego
Abstract excerpt
PURPOSE: Most common forms of human epilepsy result from a complex combination of polygenetic and environmental factors. Quantitative trait locus (QTL) mapping is a first step toward the nonbiased discovery of epilepsy-related candidate genes. QTL studies of susceptibility to induced seizures in mouse strains have consistently converged on a distal region of chromosome 1 as a major phenotypic determinant;...
Topics
- Animals
- Animals, Congenic
- Brain
- Chromosome Mapping
- Electroencephalography
- Epilepsy, Absence
- Genetic Predisposition to Disease
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Quantitative Trait Loci