Article
Genetic and phenotypic analysis of seizure susceptibility in PL/J mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2004
Kitami Toshimori, Ernest Sheila, Gallaugher Laura, Friedman Lee, Frankel Wayne N, Nadeau Joseph H
Abstract excerpt
Epilepsy is one of the most common but genetically complex neurological disorders in humans. Identifying animal models that recapitulate human epilepsies is important for pharmacological studies of anticonvulsants, dissection of molecular and biochemical pathogenesis of epilepsy, and discovery of epilepsy susceptibility genes. We discovered that the PL/J inbred mouse strain is susceptible to handling- and...
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