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Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype

1 Jan 2024

Abstract excerpt

The present single-cell study revealed the cellular repertoire and cell-of-origin patterns of breast cancer. Combining single-cell and bulk transcriptome data, we elucidated the evolution mimicry from normal to malignant subtypes and expounded the LP subtype with vital clinical implications. Novel immune and stromal cell subpopulations of breast cancer identified in our study could be potential therapeutic...

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PMID: 38855191
DOI: 10.7150/thno.96163

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