Article
Impact of numerical variation in FMS-like tyrosine kinase receptor 3 internal tandem duplications on clinical outcome in normal karyotype acute myelogenous leukemia.
Cancer - 1 Dec 2012
Borthakur Gautam, Kantarjian Hagop, Patel Keyur P, Ravandi Farhad, Qiao Wei, Faderl Stefan, Kadia Tapan, Luthra Raja, Pierce Sherry, Cortes Jorge E
Abstract excerpt
BACKGROUND: The impact of single versus multiple fms-like tyrosine kinase receptor 3 internal tandem duplication (FLT3-ITD) mutations on the clinical outcome of patients with acute myelogenous leukemia has not been well studied, and particularly has not been investigated while simultaneously accounting for the quantitative mutation burden. METHODS: The authors conducted a multivariate analysis of overall...
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