Article
Lung cancer in never-smokers. Does smoking history matter in the era of molecular diagnostics and targeted therapy?
Journal of clinical pathology - 1 Oct 2013
Ou Sai-Hong Ignatius
Abstract excerpt
Lung cancer in never-smokers was recognised as a distinct clinical entity around the mid-2000s because these patients tended to be Asian women and diagnosed at a younger age with a preponderance of adenocarcinoma and better survival outcome despite a more advanced stage of presentation. It was soon discovered that lung cancer in never-smokers had a higher prevalence of activating EGFR mutations and we tend to...
Topics
- Adenocarcinoma
- Adenocarcinoma of Lung
- Anaplastic Lymphoma Kinase
- Biomarkers, Tumor
- Carcinoma, Non-Small-Cell Lung
- ErbB Receptors
- Female
- Gene Rearrangement
- Genetic Predisposition to Disease
- Humans
- Lung Neoplasms