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Article

The roles of tryptophans in primer synthesis by the DNA primase of bacteriophage T7.

The Journal of biological chemistry - 6 Jul 2012

Zhang Huidong, Lee Seung-Joo, Richardson Charles C

Abstract excerpt

DNA primases catalyze the synthesis of oligoribonucleotides required for the initiation of lagging strand DNA synthesis. Prokaryotic primases consist of a zinc-binding domain (ZBD) necessary for recognition of a specific template sequence and a catalytic RNA polymerase domain. Interactions of both domains with the DNA template and ribonucleotides are required for primer synthesis. Five tryptophan residues are...

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Identifiers

PMID: 22605336
DOI: 10.1074/jbc.M112.366096
PMCID: PMC3390639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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