Article
Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity.
Human molecular genetics - 15 Aug 2012
El-Sayed Moustafa Julia S, Eleftherohorinou Hariklia, de Smith Adam J, Andersson-Assarsson Johanna C, Alves Alexessander Couto, Hadjigeorgiou Eleni, Walters Robin G, Asher Julian E, Bottolo Leonardo, Buxton Jessica L, Sladek Rob, Meyre David, Dina Christian, Visvikis-Siest Sophie, Jacobson Peter, Sjöström Lars, Carlsson Lena M S, Walley Andrew, Falchi Mario, Froguel Philippe, Blakemore Alexandra I F, Coin Lachlan J M
Abstract excerpt
Variable number tandem repeats (VNTRs) constitute a relatively under-examined class of genomic variants in the context of complex disease because of their sequence complexity and the challenges in assaying them. Recent large-scale genome-wide copy number variant mapping and association efforts have highlighted the need for improved methodology for association studies using these complex polymorphisms. Here we...
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