Article
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
Nature genetics - 1 Jan 2009
Thorleifsson Gudmar, Walters G Bragi, Gudbjartsson Daniel F, Steinthorsdottir Valgerdur, Sulem Patrick, Helgadottir Anna, Styrkarsdottir Unnur, Gretarsdottir Solveig, Thorlacius Steinunn, Jonsdottir Ingileif, Jonsdottir Thorbjorg, Olafsdottir Elinborg J, Olafsdottir Gudridur H, Jonsson Thorvaldur, Jonsson Frosti, Borch-Johnsen Knut, Hansen Torben, Andersen Gitte, Jorgensen Torben, Lauritzen Torsten, Aben Katja K, Verbeek André L M, Roeleveld Nel, Kampman Ellen, Yanek Lisa R, Becker Lewis C, Tryggvadottir Laufey, Rafnar Thorunn, Becker Diane M, Gulcher Jeffrey, Kiemeney Lambertus A, Pedersen Oluf, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined...
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