Article
Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity.
Human molecular genetics - 1 Dec 2015
Hägg Sara, Ganna Andrea, Van Der Laan Sander W, Esko Tonu, Pers Tune H, Locke Adam E, Berndt Sonja I, Justice Anne E, Kahali Bratati, Siemelink Marten A, Pasterkamp Gerard, Strachan David P, Speliotes Elizabeth K, North Kari E, Loos Ruth J F, Hirschhorn Joel N, Pawitan Yudi, Ingelsson Erik
Abstract excerpt
To date, genome-wide association studies (GWASs) have identified >100 loci with single variants associated with body mass index (BMI). This approach may miss loci with high allelic heterogeneity; therefore, the aim of the present study was to use gene-based meta-analysis to identify regions with high allelic heterogeneity to discover additional obesity susceptibility loci. We included GWAS data from 123 865...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.