Article
Phenotypic plasticity of grafted catecholaminergic cells in the dopamine-depleted caudate nucleus in the rat.
Neuroscience research. Supplement : the official journal of the Japan Neuroscience Society - 1 Jan 1990
Nishino H, Hashitani T, Kumazaki M
Abstract excerpt
Catecholamine-producing cells were grafted in the caudate nucleus of model rats with hemi-Parkinson's disease--animals with unilateral 6-hydroxydopamine (6-OHDA) lesions in the nigrostriatal dopaminergic pathway. Survival of the grafted cells, dopamine synthesis/release, and recovery from motor imbalance were investigated. Motor imbalance (methamphetamine rotations) recovered in more than 90% of animals by...
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