Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats.

Neuroreport - 27 Apr 2000

Leone P, McPhee S W, Janson C G, Davidson B L, Freese A, During M J

Abstract excerpt

Parkinson's disease (PD) is a leading candidate for neurological gene therapy, given our increasing knowledge of the functional anatomy of the striatonigral system and the localized nature of the affected cell populations. Here we report that stereotactic introduction of a human tyrosine hydroxylase (TH-2) gene using multi-site partitioned doses resulted in behavioral recovery in 6-OHDA-lesioned rats, with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Corpus Striatum
Share to Gene Transfer Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oxidopamine

Share to Parkinson Disease, Secondary

Share to Rats, Inbred F344

Share to Recovery of Function

Share to Tyrosine 3-Monooxygenase

Source

Identifiers

PMID: 10817582
DOI: 10.1097/00001756-200004270-00002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats.PMID 10817582Read ↗

Long-term phenotypic correction of rodent hemiparkinsonism by gene therapy using genetically modified myoblasts.Semantic proximity Read ↗

Controlled Striatal DOPA Production From a Gene Delivery System in a Rodent Model of Parkinson's Disease.Semantic proximity Read ↗

Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's DiseaseSemantic proximity Read ↗

Transplanted human neural precursor cells migrate widely but show no lesion-specific tropism in the 6-hydroxydopamine rat model of Parkinson's disease.Semantic proximity Read ↗

Gene therapy for Parkinson's diseaseSemantic proximity Read ↗

Dopamine Gene Therapy for Parkinson’s Disease in a Nonhuman Primate Without Associated DyskinesiaSemantic proximity Read ↗

Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.Semantic proximity Read ↗

Gene therapy for Parkinson’s disease: contemporary practice and emerging conceptsSemantic proximity Read ↗

Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion.Semantic proximity Read ↗

Phenotypic plasticity of grafted catecholaminergic cells in the dopamine-depleted caudate nucleus in the rat.Semantic proximity Read ↗

Glial cell line‐derived neurotrophic factor–secreting genetically modified human bone marrow‐derived mesenchymal stem cells promote recovery in a rat model of Parkinson's diseaseSemantic proximity Read ↗

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in ratSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.