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Article

Assessment of Humoral, Innate, and T-Cell Immune Responses to Adeno-Associated Virus Vectors

1 Apr 2018

Abstract excerpt

Adeno-associated virus (AAV)-based gene therapy is being applied to treat a wide array of diseases. Preexisting host immune responses to AAV and immune responses elicited by AAV vector administration remain a problem that needs to be further studied. Here we present a series of protocols to assess immune responses before and after AAV vector administration that are applicable to multiple animal models and phase 1...

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PMID: 29668327
DOI: 10.1089/hgtb.2018.038

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