Article
Characterization of miR-122-independent propagation of HCV.
PLoS pathogens - 1 May 2017
Ono Chikako, Fukuhara Takasuke, Motooka Daisuke, Nakamura Shota, Okuzaki Daisuke, Yamamoto Satomi, Tamura Tomokazu, Mori Hiroyuki, Sato Asuka, Uemura Kentaro, Fauzyah Yuzy, Kurihara Takeshi, Suda Takahiro, Nishio Akira, Hmwe Su Su, Okamoto Toru, Tatsumi Tomohide, Takehara Tetsuo, Chayama Kazuaki, Wakita Takaji, Koike Kazuhiko, Matsuura Yoshiharu
Abstract excerpt
miR-122, a liver-specific microRNA, is one of the determinants for liver tropism of hepatitis C virus (HCV) infection. Although miR-122 is required for efficient propagation of HCV, we have previously shown that HCV replicates at a low rate in miR-122-deficient cells, suggesting that HCV-RNA is capable of propagating in an miR-122-independent manner. We herein investigated the roles of miR-122 in both the...
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