Article
Brain-derived neurotrophic factor Val66Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study.
Molecular psychiatry - 1 Apr 2018
Wei S-M, Baller E B, Kohn P D, Kippenhan J S, Kolachana B, Soldin S J, Rubinow D R, Schmidt P J, Berman K F
Abstract excerpt
Preclinical evidence suggests that the actions of ovarian steroid hormones and brain-derived neurotrophic factor (BDNF) are highly convergent on brain function. Studies in humanized mice document an interaction between estrus cycle-related changes in estradiol secretion and BDNF Val66Met genotype on measures of hippocampal function and anxiety-like behavior. We believe our multimodal imaging data provide the...
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