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Article

Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus.

Scientific reports - 7 Jun 2016

Chai Hangzhen, Yin Ru, Liu Yongfeng, Meng Huiying, Zhou Xianqiang, Zhou Guolin, Bi Xupeng, Yang Xue, Zhu Tonghan, Zhu Weiming, Deng Zixin, Hong Kui

Abstract excerpt

Terpenoids are the most diverse and abundant natural products among which sesterterpenes account for less than 2%, with very few reports on their biosynthesis. Ophiobolins are tricyclic 5-8-5 ring sesterterpenes with potential pharmaceutical application. Aspergillus ustus 094102 from mangrove rizhosphere produces ophiobolin and other terpenes. We obtained five gene cluster knockout mutants, with altered...

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PMID: 27273151
DOI: 10.1038/srep27181
PMCID: PMC4895135

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