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Article

European American stratification in ovarian cancer case control data: the utility of genome-wide data for inferring ancestry.

PloS one - 1 Jan 2012

Raska Paola, Iversen Edwin, Chen Ann, Chen Zhihua, Fridley Brooke L, Permuth-Wey Jennifer, Tsai Ya-Yu, Vierkant Robert A, Goode Ellen L, Risch Harvey, Schildkraut Joellen M, Sellers Thomas A, Barnholtz-Sloan Jill

Abstract excerpt

We investigated the ability of several principal components analysis (PCA)-based strategies to detect and control for population stratification using data from a multi-center study of epithelial ovarian cancer among women of European-American ethnicity. These include a correction based on an ancestry informative markers (AIMs) panel designed to capture European ancestral variation and corrections utilizing...

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PMID: 22590501
DOI: 10.1371/journal.pone.0035235
PMCID: PMC3348917

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