Article
Loss of Gnas imprinting differentially affects REM/NREM sleep and cognition in mice.
PLoS genetics - 1 Jan 2012
Lassi Glenda, Ball Simon T, Maggi Silvia, Colonna Giovanni, Nieus Thierry, Cero Cheryl, Bartolomucci Alessandro, Peters Jo, Tucci Valter
Abstract excerpt
It has been suggested that imprinted genes are important in the regulation of sleep. However, the fundamental question of whether genomic imprinting has a role in sleep has remained elusive up to now. In this work we show that REM and NREM sleep states are differentially modulated by the maternally expressed imprinted gene Gnas. In particular, in mice with loss of imprinting of Gnas, NREM and complex cognitive...
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