Article
Impulsive choices in mice lacking imprinted Nesp55.
Genes, brain, and behavior - 1 Nov 2016
Dent C L, Humby T, Lewis K, Plagge A, Fischer-Colbrie R, Wilkins J F, Wilkinson L S, Isles A R
Abstract excerpt
Genomic imprinting is the process whereby germline epigenetic events lead to parent-of-origin specific monallelic expression of a number of key mammalian genes. The imprinted gene Nesp is expressed from the maternal allele only and encodes for Nesp55 protein. In the brain, Nesp55 is found predominately in discrete areas of the hypothalamus and midbrain. Previously, we have shown that loss of Nesp55 gives rise to...
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