Article

Loss of SNORD115 mitigates SNORD116-driven sleep abnormalities in mouse models of Prader-Willi syndrome

2026-04-30

Abstract excerpt

Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the loss of paternally expressed genes within the imprinted 15q11-q13 locus, which includes clusters of box C/D small nucleolar RNAs (SNORDs), notably the SNORD115 and SNORD116 gene families. Although paternally inherited SNORD116 deletions have been associated with sleep disturbances in patients and mouse models, the respective and combined co...

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Literature Corpus work: 1073eef9-e856-5628-aa27-66d793014dbe
DOI: 10.64898/2026.04.28.720143

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