Article
Finding Direction in the Search for Selection.
Journal of molecular evolution - 1 Jan 2017
Thiltgen Grant, Dos Reis Mario, Goldstein Richard A
Abstract excerpt
Tests for positive selection have mostly been developed to look for diversifying selection where change away from the current amino acid is often favorable. However, in many cases we are interested in directional selection where there is a shift toward specific amino acids, resulting in increased fitness in the species. Recently, a few methods have been developed to detect and characterize directional selection...
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