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Article

Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke.

Cancer discovery - 1 Oct 2011

Spitz Margaret R, Gorlov Ivan P, Amos Christopher I, Dong Qiong, Chen Wei, Etzel Carol J, Gorlova Olga Y, Chang David W, Pu Xia, Zhang Di, Wang Liang, Cunningham Julie M, Yang Ping, Wu Xifeng

Abstract excerpt

Lung cancer in lifetime never smokers is distinct from that in smokers, but the role of separate or overlapping carcinogenic pathways has not been explored. We therefore evaluated a comprehensive panel of 11,737 single-nucleotide polymorphisms (SNP) in inflammatory-pathway genes in a discovery phase (451 lung cancer cases, 508 controls from Texas). SNPs that were significant were evaluated in a second external...

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Identifiers

PMID: 22586632
DOI: 10.1158/2159-8290.CD-11-0080
PMCID: PMC3919666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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