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Germline variants of the genes involved in NF-kB activation are associated with the risk of COPD and lung cancer development.

Acta pharmaceutica (Zagreb, Croatia) - 1 Jun 2023

Baranasic Jurica, Niazi Yasmeen, Chattopadhyay Subhayan, Rumora Lada, Ćorak Lorna, Dugac Andrea Vukić, Jakopović Marko, Samaržija Miroslav, Försti Asta, Knežević Jelena

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are closely related diseases associated with smoking history and dysregulated immune response. However, not all smokers develop the disease, indicating that genetic susceptibility could be important. Therefore, the aim of this study was to search for the potential overlapping genetic biomarkers, with a focus on single nucleotide polymorphisms...

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PMID: 37307368
DOI: 10.2478/acph-2023-0019

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