Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers.

doi:10.1002/ijc.25214

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Article

Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers.

International journal of cancer - 1 Nov 2010

Oh Sam S, Chang Shen-Chih, Cai Lin, Cordon-Cardo Carlos, Ding Bao-Guo, Greenland Sander, He Na, Jiang Qingwu, Kheifets Leeka, Le Anh, Lee Yuan-Chin Amy, Liu Simin, Lu Ming-Lan, Mao Jenny T, Morgenstern Hal, Mu Li-Na, Pantuck Allan, Papp Jeanette C, Park Sungshim Lani, Rao Jian Yu, Reuter Victor E, Tashkin Donald P, Wang Hua, You Nai-Chieh Y, Yu Shun-Zhang, Zhao Jin-Kou, Belldegrun Arie, Zhang Zuo-Feng

Abstract excerpt

Tobacco smoke and its metabolites are carcinogens that increase tissue oxidative stress and induce target tissue inflammation. We hypothesized that genetic variation of inflammatory pathway genes plays a role in tobacco-related carcinogenesis and is modified by tobacco smoking. We evaluated the association of 12 single nucleotide polymorphisms of 8 inflammation-related genes with tobacco-related cancers (lung,...

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PMID: 20112337
DOI: 10.1002/ijc.25214
PMCID: PMC2932751

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