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Article

Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.

European journal of human genetics : EJHG - 1 Jun 2021

Cotroneo Chiara E, Mangano Nunzia, Dragani Tommaso A, Colombo Francesca

Abstract excerpt

Germline variants in genes involved in SARS-CoV-2 cell entry and in host innate immune responses to viruses may influence the susceptibility to infection. This study used whole-genome analyses of lung tissue to identify polymorphisms acting as expression quantitative trait loci (eQTLs) for 60 genes of relevance to SARS-CoV-2 infection susceptibility. The expression of genes with confirmed or possible roles in...

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Identifiers

PMID: 33649539
DOI: 10.1038/s41431-021-00831-y
PMCID: PMC7917374

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