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Article

Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2012

Zhang Xulun, Hoey Robert J, Lin Guoqing, Koide Akiko, Leung Brenda, Ahn Kwangwook, Dolios Georgia, Paduch Marcin, Ikeuchi Takeshi, Wang Rong, Li Yue-Ming, Koide Shohei, Sisodia Sangram S

Abstract excerpt

The γ-secretase complex, composed of presenilin, anterior-pharynx-defective 1, nicastrin, and presenilin enhancer 2, catalyzes the intramembranous processing of a wide variety of type I membrane proteins, including amyloid precursor protein (APP) and Notch. Earlier studies have revealed that nicastrin, a type I membrane-anchored glycoprotein, plays a role in γ-secretase assembly and trafficking and has been...

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Share to Amyloid Precursor Protein Secretases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22586122
DOI: 10.1073/pnas.1202691109
PMCID: PMC3365189

Genes

TPR
APP
DAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies.PMID 22586122Read ↗

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