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Article

Structure and function of gamma-secretase.

Seminars in cell & developmental biology - 1 Apr 2009

Tolia Alexandra, De Strooper Bart

Abstract excerpt

The gamma-secretase complex is a prime target for pharmacological intervention in Alzheimer's disease and so far drug discovery efforts have yielded a large variety of potent and rather specific inhibitors of this enzymatic activity. However, as gamma-secretase is able to cleave a wide variety of...

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Identifiers

PMID: 19007897
DOI: 10.1016/j.semcdb.2008.10.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19007897-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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