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Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins.

Methods in enzymology - 1 Jan 2017

Veugelen S, Dewilde M, De Strooper B, Chávez-Gutiérrez L

Abstract excerpt

The study of membrane protein function and structure requires their successful detection, expression, solubilization, and/or reconstitution, which poses a challenging task and relies on the availability of suitable tools. Several research groups have successfully applied Nanobodies in the purification, as well as the functional and structural characterization of membrane proteins. Nanobodies are small,...

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PMID: 28065273
DOI: 10.1016/bs.mie.2016.10.029

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