Article
Increased lipoprotein oxidation in Alzheimer's disease.
Free radical biology & medicine - 1 Feb 2000
Schippling S, Kontush A, Arlt S, Buhmann C, Stürenburg H J, Mann U, Müller-Thomsen T, Beisiegel U
Abstract excerpt
Oxidation has been proposed to be an important factor in the pathogenesis of Alzheimer's disease (AD) and amyloid beta is considered to induce oxidation. In biological fluids, including cerebrospinal fluid (CSF), amyloid beta is found complexed to lipoproteins. On the basis of these observations, we investigated the potential role of lipoprotein oxidation in the pathology of AD. Lipoprotein oxidizability was...
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