Article
Evidence of oxidative stress in familial amyloidotic polyneuropathy type 1.
Archives of neurology - 1 Apr 2003
Fiszman Mónica L, Di Egidio Marianna, Ricart Karina C, Repetto Marisa G, Borodinsky Laura N, Llesuy Susana F, Saizar Roberto D, Trigo Pedro L, Riedstra Symon, Costa Paulo P, Villa Andrés M, Katz Nestor, Lendoire Javier C, Sica Roberto E P
Abstract excerpt
OBJECTIVE: To evaluate the oxidative state in patients with familial amyloidotic polyneuropathy type 1 (FAP1). DESIGN: From 3 unrelated families, patients with FAP1 carrying a transthyretin Met-30 mutation were studied. The diagnosis was confirmed by genetic analysis. Eleven of 21 patients carried the mutation; all were symptomatic and were clinically assessed using a clinical score. All of the patients were...
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