Article
Structural and functional neuroimaging phenotypes in dysbindin mutant mice.
NeuroImage - 1 Aug 2012
Lutkenhoff Evan, Karlsgodt Katherine H, Gutman Boris, Stein Jason L, Thompson Paul M, Cannon Tyrone D, Jentsch J David
Abstract excerpt
Schizophrenia is a highly heritable psychiatric disorder that is associated with a number of structural and functional neurophenotypes. DTNBP1, the gene encoding dysbindin-1, is a promising candidate gene for schizophrenia. Use of a mouse model carrying a large genomic deletion exclusively within the dysbindin gene permits a direct investigation of the gene in isolation. Here, we use manganese-enhanced magnetic...
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