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Article

MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts.

Circulation research - 3 Jan 2014

Wang Daren, Zhang Hui, Li Min, Frid Maria G, Flockton Amanda R, McKeon B Alexandre, Yeager Michael E, Fini Mehdi A, Morrell Nicholas W, Pullamsetti Soni S, Velegala Sivareddy, Seeger Werner, McKinsey Timothy A, Sucharov Carmen C, Stenmark Kurt R

Abstract excerpt

RATIONALE: Pulmonary hypertensive remodeling is characterized by excessive proliferation, migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts maintain a similar activated phenotype. The mechanisms responsible for generation/maintenance of this phenotype remain unknown. OBJECTIVE: We hypothesized that aberrant expression of microRNA-124 (miR-124) regulates this activated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24122720
DOI: 10.1161/CIRCRESAHA.114.301633
PMCID: PMC4117588

Genes

FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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