Article
Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall.
American journal of physiology. Lung cellular and molecular physiology - 1 Dec 2009
Frid Maria G, Li Min, Gnanasekharan Meena, Burke Danielle L, Fragoso Miguel, Strassheim Derek, Sylman Joanna L, Stenmark Kurt R
Abstract excerpt
All forms of chronic pulmonary hypertension (PH) are characterized by structural remodeling of the pulmonary artery (PA) media, a process previously attributed solely to changes in the phenotype of resident smooth muscle cells (SMC). However, recent experimental evidence in both systemic and pulmonary circulations suggests that other cell types, including circulating and local progenitors, contribute...
Topics
- Animals
- Autocrine Communication
- Biomarkers
- Cattle
- Cell Movement
- Cell Proliferation
- Cells, Cultured
- Chemokine CXCL12
- Culture Media
- Gene Expression Regulation