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Article

Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension.

American journal of physiology. Lung cellular and molecular physiology - 1 Oct 2006

Ihida-Stansbury Kaori, McKean David M, Lane Kirk B, Loyd James E, Wheeler Lisa A, Morrell Nicholas W, Jones Peter Lloyd

Abstract excerpt

Familial forms of human pulmonary arterial hypertension (FPAH) have been linked to mutations in bone morphogenetic protein (BMP) type II receptors (BMPR2s), yet the downstream targets of these receptors remain obscure. Here we show that pulmonary vascular lesions from patients harboring BMPR2 mutations express high levels of tenascin-C (TN-C), an extracellular matrix glycoprotein that promotes pulmonary artery...

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Share to Bone Morphogenetic Protein Receptors, Type II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

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Source

Identifiers

PMID: 16782755
DOI: 10.1152/ajplung.00119.2006

Genes

BMPR2
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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