Article
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency.
Science (New York, N.Y.) - 8 Jun 2012
Vos Melissa, Esposito Giovanni, Edirisinghe Janaka N, Vilain Sven, Haddad Dominik M, Slabbaert Jan R, Van Meensel Stefanie, Schaap Onno, De Strooper Bart, Meganathan R, Morais Vanessa A, Verstreken Patrik
Abstract excerpt
Human UBIAD1 localizes to mitochondria and converts vitamin K(1) to vitamin K(2). Vitamin K(2) is best known as a cofactor in blood coagulation, but in bacteria it is a membrane-bound electron carrier. Whether vitamin K(2) exerts a similar carrier function in eukaryotic cells is unknown. We identified Drosophila UBIAD1/Heix as a modifier of pink1, a gene mutated in Parkinson's disease that affects mitochondrial...
Topics
- Adenosine Triphosphate
- Animals
- Drosophila
- Drosophila Proteins
- Electron Transport
- Escherichia coli
- Flight, Animal
- Genes, Insect
- Membrane Potential, Mitochondrial
- Mitochondria