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Article

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

11 May 2012

Abstract excerpt

Cellular oxidative and electrophilic stress triggers a protective response in mammals regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes. Studies using Nrf2-deficient mice suggest that hundreds of genes may be regulated by NRF2. To identify human NRF2-regulated genes, we conducted chromatin immunoprecipitation...

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PMID: 22581777
DOI: 10.1093/nar/gks409

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