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Article

NRF2/long noncoding RNA ROR signaling regulates mammary stem cell expansion and protects against estrogen genotoxicity.

The Journal of biological chemistry - 7 Nov 2014

Zhang Yongshu, Xia Jixiang, Li Qinglin, Yao Yuan, Eades Gabriel, Gernapudi Ramkishore, Duru Nadire, Kensler Thomas W, Zhou Qun

Abstract excerpt

Long noncoding RNAs (lncRNAs) have emerged as key regulators of gene expression in embryonic stem cell (ESC) self-renewal and differentiation. In ESCs, lncRNAs are regulated at the genetic level via transcription factor binding to lncRNA gene promoters. Here we demonstrate that the key cytoprotective transcription factor NRF2 controls lncRNA expression in mammary stem cells. By profiling lncRNAs in wild-type and...

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Identifiers

PMID: 25231996
DOI: 10.1074/jbc.M114.604868
PMCID: PMC4223331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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