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Article

Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2.

Human molecular genetics - 15 Jan 2013

Hansen Stephen T, Meera Pratap, Otis Thomas S, Pulst Stefan M

Abstract excerpt

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited disorder, which is caused by a pathological expansion of a polyglutamine (polyQ) tract in the coding region of the ATXN2 gene. Like other ataxias, SCA2 most overtly affects Purkinje cells (PCs) in the cerebellum. Using a transgenic mouse model expressing a full-length ATXN2(Q127)-complementary DNA under control of the Pcp2 promoter (a...

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Source

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Identifiers

PMID: 23087021
DOI: 10.1093/hmg/dds427
PMCID: PMC3526159

Genes

ATXN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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