Article
Genome-wide association studies and infectious disease.
Critical reviews in immunology - 1 Jan 2010
Bowcock Anne M
Abstract excerpt
The identification of genetic variants predisposing to complex diseases and phenotypes represent a challenge for geneticists in the early part of the 21st century. These are not simple Mendelian disorders caused by single mutations, such as cystic fibrosis or Huntington's disease, but common diseases that are usually polygenic in origin. The predisposing genes can be susceptibility factors or protective factors....
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