Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Natalizumab Affects T-Cell Phenotype in Multiple Sclerosis: Implications for JCV Reactivation.

PloS one - 1 Jan 2016

Iannetta Marco, Zingaropoli Maria Antonella, Bellizzi Anna, Morreale Manuela, Pontecorvo Simona, D'Abramo Alessandra, Oliva Alessandra, Anzivino Elena, Lo Menzo Sara, D'Agostino Claudia, Mastroianni Claudio Maria, Millefiorini Enrico, Pietropaolo Valeria, Francia Ada, Vullo Vincenzo, Ciardi Maria Rosa

Abstract excerpt

The anti-CD49d monoclonal antibody natalizumab is currently an effective therapy against the relapsing-remitting form of multiple sclerosis (RRMS). Natalizumab therapeutic efficacy is limited by the reactivation of the John Cunningham polyomavirus (JCV) and development of progressive multifocal leukoencephalopathy (PML). To correlate natalizumab-induced phenotypic modifications of peripheral blood T-lymphocytes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Viral
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to JC Virus

Share to Leukoencephalopathy, Progressive Multifocal

Share to Multiple Sclerosis, Relapsing-Remitting

Share to T-Lymphocytes

Share to Treatment Outcome

Share to Virus Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 27486658
DOI: 10.1371/journal.pone.0160277
PMCID: PMC4972347

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Natalizumab Affects T-Cell Phenotype in Multiple Sclerosis: Implications for JCV Reactivation.PMID 27486658Read ↗

Immune surveillance in multiple sclerosis patients treated with natalizumab.Semantic proximity Read ↗

Low memory T cells blood counts and high naïve regulatory T cells percentage at relapsing remitting multiple sclerosis diagnosisSemantic proximity Read ↗

Association of B-cell activating factor gene variants with serum anti-JCV antibody positivity in male patients with multiple sclerosis under natalizumab treatment: Implications for progressive multifocal leukoencephalopathy risk stratification.Semantic proximity Read ↗

Encephalitogenic and Regulatory CD8 T Cells in Multiple Sclerosis and Its Animal ModelsSemantic proximity Read ↗

Analysis of CD4+ CD8+ double-positive T cells in blood, cerebrospinal fluid and multiple sclerosis lesions.Semantic proximity Read ↗

Multiparametric flow cytometric analysis of whole blood reveals changes in minor lymphocyte subpopulations of multiple sclerosis patients.Semantic proximity Read ↗

Ocrelizumab Impairs the Phenotype and Function of Memory CD8+ T Cells: A 1-Year Longitudinal Study in Patients With Multiple Sclerosis.Semantic proximity Read ↗

Long-term follow-up of peripheral lymphocyte subsets in a cohort of multiple sclerosis patients treated with natalizumab.Semantic proximity Read ↗

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?Semantic proximity Read ↗

B-Cell and T-Cell Populations in Peripheral Blood Linked to Ocrelizumab Treatment Efficacy in Multiple SclerosisSemantic proximity Read ↗

Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy.Semantic proximity Read ↗

Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.