Article
Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening.
American journal of human genetics - 13 May 2011
So Hon-Cheong, Kwan Johnny S H, Cherny Stacey S, Sham Pak C
Abstract excerpt
Risk prediction based on genomic profiles has raised a lot of attention recently. However, family history is usually ignored in genetic risk prediction. In this study we proposed a statistical framework for risk prediction given an individual's genotype profile and family history. Genotype information about the relatives can also be incorporated. We allow risk prediction given the current age and follow-up period...
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