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Article

EGFR status and KRAS/BRAF mutations in intestinal-type sinonasal adenocarcinomas.

Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2012

García-Inclán Cristina, López Fernando, Pérez-Escuredo Jhudit, Cuesta-Albalad Mari Paz, Vivanco Blanca, Centeno Irene, Balbín Milagros, Suárez Carlos, Llorente José Luis, Hermsen Mario A

Abstract excerpt

BACKGROUND: Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumour that is etiologically related to professional exposure to wood dust and exhibits a poor prognosis. Treatment alternatives to surgery and radiotherapy are needed and may be found in anti-EGFR agents. EGFR gene copy number gains and KRAS/BRAF mutations have been reported to act as positive and negative predictors, respectively, of...

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Identifiers

PMID: 23055340
DOI: 10.1007/s13402-012-0103-7
PMCID: PMC12995005

Genes

EGFR
BRAF
KRAS

Provenance

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